Medical Microbiology and Immunology

Research Output 1953 2019

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2019

An Experimental Approach to Rigorously Assess Paneth Cell α-Defensin (Defa) mRNA Expression in C57BL/6 Mice

Castillo, P. A., Nonnecke, E. B., Ossorio, D. T., Tran, M. T. N., Goley, S. M., Lönnerdal, B., Underwood, M. & Bevins, C. L., Sep 11 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Paneth Cells
Defensins
Inbred C57BL Mouse
Messenger RNA
Peptides
2 Citations (Scopus)

An Exploratory Examination of Neonatal Cytokines and Chemokines as Predictors of Autism Risk: The Early Markers for Autism Study

Heuer, L. S., Croen, L. A., Jones, K. L., Yoshida, C. K., Hansen, R. L., Yolken, R., Zerbo, O., DeLorenze, G., Kharrazi, M., Ashwood, P. & Van de Water, J. A., Jan 1 2019, In : Biological Psychiatry.

Research output: Contribution to journalArticle

Autistic Disorder
Chemokines
Cytokines
Biomarkers
Population Control

Bacterial Colonization of the Hospitalized Newborn: Competition Between Staphylococcus aureus and Staphylococcus epidermidis

Lee, D. C., Kananurak, A., Tran, M. T., Connolly, P. A., Polage, C. R., Iwase, T., Bevins, C. L. & Underwood, M., Jul 1 2019, In : The Pediatric infectious disease journal. 38, 7, p. 682-686 5 p.

Research output: Contribution to journalArticle

Staphylococcus epidermidis
Staphylococcus aureus
Newborn Infant
Peptide Hydrolases
Biofilms

BK virus replication in the glomerular vascular unit: Implications for BK virus associated nephropathy

Popik, W., Khatua, A. K., Fabre, N. F., Hildreth, J. & Alcendor, D. J., Jul 1 2019, In : Viruses. 11, 7, 583.

Research output: Contribution to journalArticle

Open Access
BK Virus
Virus Replication
Blood Vessels
Podocytes
Mesangial Cells

Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP

Byndloss, M. X., Tsai, A. Y., Walker, G. T., Miller, C. N., Young, B. M., English, B. C., Seyffert, N., Kerrinnes, T., de Jong, M. F., Atluri, V. L., Winter, M. G., Celli, J. & Tsolis, R. M., Jul 23 2019, In : mBio. 10, 4

Research output: Contribution to journalArticle

Open Access
Brucella abortus
Endoplasmic Reticulum Stress
Trophoblasts
Cell Death
Infection
4 Citations (Scopus)

Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition

Litvak, Y., Mon, K. K. Z., Nguyen, H., Chanthavixay, G., Liou, M., Velazquez, E. M., Kutter, L., Alcantara, M. A., Byndloss, M. X., Tiffany, C. R., Walker, G. T., Faber, F., Zhu, Y., Bronner, D. N., Byndloss, A. J., Tsolis, R. M., Zhou, H. & Baumler, A. J., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 128-139.e5

Research output: Contribution to journalArticle

Enterobacteriaceae
Salmonella
Oxygen
Escherichia coli
Spores
1 Citation (Scopus)

Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate

Jiang, G., Maverakis, E. M., Cheng, M. Y., Elsheikh, M. M., Deleage, C., Méndez-Lagares, G., Shimoda, M., Yukl, S. A., Hartigan-O'Connor, D., Thompson, G. R., Estes, J. D., Wong, J. K. & Dandekar, S., Jan 1 2019, In : JCI Insight. 4, 7, e126027.

Research output: Contribution to journalArticle

Open Access
Actinic Keratosis
HIV
Skin
Biopsy
Therapeutics

Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo

Cavrois, M., Hilton, J. F., Roan, N. R., Takeda, M., Seidman, D., Averbach, S., Chang, E., Raman, N., Greenblatt, R., Shacklett, B. & Smith-McCune, K., Jan 1 2019, In : PloS one. 14, 8, e0221181.

Research output: Contribution to journalArticle

Open Access
Copper Intrauterine Devices
oral contraceptives
Levonorgestrel
Intrauterine Devices
cervix
6 Citations (Scopus)

Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection

Velazquez, E. M., Nguyen, H., Heasley, K. T., Saechao, C. H., Gil, L. M., Rogers, A. W. L., Miller, B. M., Rolston, M. R., Lopez, C. A., Litvak, Y., Liou, M. J., Faber, F., Bronner, D. N., Tiffany, C. R., Byndloss, M. X., Byndloss, A. J. & Baumler, A. J., Jan 1 2019, In : Nature Microbiology.

Research output: Contribution to journalArticle

Salmonella Infections
Enterobacteriaceae
Microbiota
Probiotics
Salmonella
1 Citation (Scopus)

Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers

Mordaunt, C. E., Kieffer, D. A., Shibata, N. M., Członkowska, A., Litwin, T., Weiss, K. H., Zhu, Y., Bowlus, C., Sarkar, S., Cooper, S., Wan, Y-J. Y., Ali, M. R., LaSalle, J. M. & Medici, V., Jan 1 2019, In : Epigenetics and Chromatin. 12, 1, 0255.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Hematologic Diseases
Epigenomics
Liver
Genome
Open Access
Point-of-Care Systems
Agglutination
Latex
agglutination
latex

Examination of fluconazole-induced alopecia in an animal model and human cohort

Thompson, G. R., Krois, C. R., Affolter, V. K., Everett, A. D., Katarina Varjonen, E., Sharon, V. R., Singapuri, A., Dennis, M., Mchardy, I. H., Yoo, H. S., Fedor, D. M., Wiederhold, N. P., Aaron, P. A., Gelli, A. C., Napoli, J. L. & White, S. D., Feb 1 2019, In : Antimicrobial Agents and Chemotherapy. 63, 2, e01384-18.

Research output: Contribution to journalArticle

Fluconazole
Alopecia
Animal Models
Tretinoin
Hair
2 Citations (Scopus)

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy

Cattin, A., Wiche Salinas, T. R., Gosselin, A., Planas, D., Shacklett, B., Cohen, E. A., Ghali, M. P., Routy, J. P. & Ancuta, P., Jul 1 2019, In : AIDS (London, England). 33, 8, p. 1293-1306 14 p.

Research output: Contribution to journalArticle

Myeloid Cells
HIV-1
Colon
HIV
Therapeutics
Endoplasmic Reticulum
niche
pathogen
secretion
Unfolded Protein Response

Increased Epithelial Oxygenation Links Colitis to an Expansion of Tumorigenic Bacteria

Cevallos, S. A., Lee, J. Y., Tiffany, C. R., Byndloss, A. J., Johnston, L., Byndloss, M. X. & Bäumler, A. J., Oct 1 2019, In : mBio. 10, 5

Research output: Contribution to journalArticle

Open Access
Microbiota
Colitis
Colorectal Neoplasms
Escherichia coli
Bacteria

Increases in HIV Incidence Following Receptive Anal Intercourse Among Women: A Systematic Review and Meta-analysis

Stannah, J., Silhol, R., Elmes, J., Owen, B., Shacklett, B., Anton, P., McGowan, I., van der Straten, A., Dimitrov, D., Baggaley, R. F. & Boily, M. C., Jan 1 2019, (Accepted/In press) In : AIDS and Behavior.

Research output: Contribution to journalArticle

Open Access
Meta-Analysis
HIV
Incidence
Interviews
Heterosexuality

Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development

Croen, L. A., Qian, Y., Ashwood, P., Zerbo, O., Schendel, D., Pinto-Martin, J., Daniele Fallin, M., Levy, S., Schieve, L. A., Yeargin-Allsopp, M., Sabourin, K. R. & Ames, J. L., Jan 1 2019, (Accepted/In press) In : Autism Research.

Research output: Contribution to journalArticle

Fever
Pregnancy
Mothers
Infection
Second Pregnancy Trimester
3 Citations (Scopus)

Isavuconazole in the treatment of coccidioidal meningitis

Heidari, A., Quinlan, M., Benjamin, D. J., Laurence, B., Mu, A., Ngai, T., Hoffman, W. J., Cohen, S. H., Mchardy, I. H., Johnson, R. & Thompson, G. R., Mar 1 2019, In : Antimicrobial Agents and Chemotherapy. e02232-18.

Research output: Contribution to journalArticle

Meningitis
Therapeutics
Salvage Therapy
isavuconazole
1 Citation (Scopus)

Metagenome-assembled genomes provide new insight into the microbial diversity of two thermal pools in Kamchatka, Russia

Wilkins, L. G. E., Ettinger, C. L., Jospin, G. & Eisen, J. A., Dec 1 2019, In : Scientific Reports. 9, 1, 3059.

Research output: Contribution to journalArticle

Open Access
Metagenome
Russia
Hot Temperature
Genome
Hot Springs

Microbial Community Succession and Nutrient Cycling Responses following Perturbations of Experimental Saltwater Aquaria

Bik, H. M., Alexiev, A., Aulakh, S. K., Bharadwaj, L., Flanagan, J., Haggerty, J. M., Hird, S. M., Jospin, G., Lang, J. M., Sauder, L. A., Neufeld, J. D., Shaver, A., Sethi, A., Eisen, J. A. & Coil, D. A., Feb 20 2019, In : mSphere. 4, 1

Research output: Contribution to journalArticle

Open Access
Food
Water
Oceans and Seas
Ecosystem
Nitrogen
1 Citation (Scopus)

Microbiota-nourishing Immunity and Its Relevance for Ulcerative Colitis

Byndloss, M. X., Litvak, Y. & Baumler, A. J., Apr 11 2019, In : Inflammatory bowel diseases. 25, 5, p. 811-815 5 p.

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Microbiota
Ulcerative Colitis
Immunity
1 Citation (Scopus)

Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus

Wang, Q., Ma, T., Wu, Y., Chen, Z., Zeng, H., Tong, Z., Gao, F., Qi, J., Zhao, Z., Chai, Y., Yang, H., Wong, G., Bi, Y., Wu, L., Shi, R., Yang, M., Song, J., Jiang, H., An, Z., Wang, J. & 7 others, Yilma, T., Shi, Y., Liu, W. J., Liang, M., Qin, C., Gao, G. F. & Yan, J., Jan 1 2019, In : Nature Microbiology.

Research output: Contribution to journalArticle

Rift Valley fever virus
Monoclonal Antibodies
Vaccines
Viral Envelope Proteins
Livestock

Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity

Deere, J. D., William Chang, W. L., Villalobos, A., Schmidt, K. A., Deshpande, A., Castillo, L. D., Fike, J., Walter, M. R., Barry, P. A. & Hartigan-O'Connor, D., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 26, p. 13036-13041 6 p.

Research output: Contribution to journalArticle

Open Access
Cytomegalovirus
Interleukin-10
Immunity
Infection
Cytomegalovirus Vaccines
1 Citation (Scopus)

Omu, a metabolomics count data analysis tool for intuitive figures and convenient metadata collection

Tiffany, C. R. & Baumler, A. J., Jan 1 2019, In : Microbiology Resource Announcements. 8, 15, e00129-19.

Research output: Contribution to journalArticle

Open Access
Molecular Sequence Annotation
Metabolomics
Workflow
Microbiota
Enzymes
3 Citations (Scopus)

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

Sanctuary, M. R., Kain, J. N., Chen, S. Y., Kalanetra, K., Lemay, D. G., Rose, D. R., Yang, H. T., Tancredi, D. J., Bruce German, J., Slupsky, C. M., Ashwood, P., Mills, D. A., Smilowitz, J. T. & Angkustsiri, K., Jan 1 2019, In : PLoS One. 14, 1, e0210064.

Research output: Contribution to journalArticle

cow colostrum
Prebiotics
Colostrum
Bifidobacterium longum subsp. infantis
Probiotics

Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study

Zhu, Y., Mordaunt, C. E., Yasui, D. H., Marathe, R., Coulson, R. L., Dunaway, K. W., Jianu, J. M., Walker, C. K., Ozonoff, S. J., Hertz-Picciotto, I., Schmidt, R. J. & LaSalle, J. M., Aug 15 2019, In : Human molecular genetics. 28, 16, p. 2659-2674 16 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
DNA Methylation
Autistic Disorder
Prospective Studies
Placenta

Rapid communication: Plasma interleukin-35 in children with Autism

Rose, D. & Ashwood, P., Jul 1 2019, In : Brain Sciences. 9, 7, 152.

Research output: Contribution to journalArticle

Open Access
Interleukins
Autistic Disorder
Communication
Anti-Inflammatory Agents
Cytokines
1 Citation (Scopus)

Species-specific inhibition of antiviral protein kinase R by capripoxviruses and vaccinia virus

Park, C., Peng, C., Brennan, G. & Rothenburg, S., Jan 1 2019, (Accepted/In press) In : Annals of the New York Academy of Sciences.

Research output: Contribution to journalArticle

Capripoxvirus
Vaccinia virus
Viruses
Protein Kinases
Antiviral Agents

T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium

Ramirez, V. T., Godinez, D. R., Brust-Mascher, I., Nonnecke, E. B., Castillo, P. A., Gardner, M. B., Tu, D., Sladek, J. A., Miller, E. N., Lebrilla, C. B., Bevins, C. L., Gareau, M. & Reardon, C., Apr 1 2019, In : PLoS pathogens. 15, 4, p. e1007719

Research output: Contribution to journalArticle

Open Access
Citrobacter rodentium
Bacterial Infections
Acetylcholine
T-Lymphocytes
Infection
2 Citations (Scopus)
Open Access
Microbiota
1 Citation (Scopus)

Tissue issues: mucosal T-cell responses in HIV-1 infection

Shacklett, B., Ferre, A. L. & Kiniry, B. E., Mar 1 2019, In : Current Opinion in HIV and AIDS. 14, 2, p. 100-107 8 p.

Research output: Contribution to journalArticle

HIV Infections
HIV-1
Mucous Membrane
T-Lymphocytes
Gastrointestinal Tract

Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights

Laufer, B. I., Hwang, H., Vogel Ciernia, A., Mordaunt, C. E. & LaSalle, J. M., Jan 1 2019, In : Epigenetics.

Research output: Contribution to journalArticle

Down Syndrome
Genome
DNA
Brain
DNA Methylation
2018
12 Citations (Scopus)

Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization

Castañeda, A. R., Pinkerton, K. E., Bein, K. J., Magaña-Méndez, A., Yang, H. T., Ashwood, P. & Vogel, C. F. A., Aug 1 2018, In : Toxicology Letters. 292, p. 85-96 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Particulate Matter
Dendritic Cells
Polarization
T-cells
3 Citations (Scopus)

Anti-Candida albicans IgG antibodies in children with autism spectrum disorders

Hughes, H. K. & Ashwood, P., Jan 1 2018, In : Frontiers in Psychiatry. 9, 627.

Research output: Contribution to journalArticle

Open Access
Candida albicans
Immunoglobulin G
Antibodies
Microbiota
Dysbiosis
6 Citations (Scopus)
Environmental Exposure
Autistic Disorder
Biomarkers
Learning
Prospective Studies

A summary of the third annual HIV microbiome workshop

Williams, B., Boucher, C., Bushman, F., Carrington-Lawrence, S., Collman, R., Dandekar, S., Dang, Q., Malaspina, A., Paredes, R., Wilson, C., Nowak, P., Klatt, N., Lagenaur, L. & Landay, A., Oct 1 2018, In : AIDS Research and Human Retroviruses. 34, 10, p. 828-834 7 p.

Research output: Contribution to journalArticle

Microbiota
HIV
Education
Virology
Health
6 Citations (Scopus)

Characterization of shifts of koala (Phascolarctos cinereus) intestinal microbial communities associated with antibiotic treatment

Dahlhausen, K. E., Doroud, L., Firl, A. J., Polkinghorne, A. & Eisen, J. A., Jan 1 2018, In : PeerJ. 2018, 3, 4452.

Research output: Contribution to journalArticle

Phascolarctidae
Phascolarctos cinereus
microbial communities
antibiotics
Anti-Bacterial Agents
3 Citations (Scopus)

Coccidioidomycosis complement fixation titer trends in the age of antifungals

Mchardy, I. H., Dinh, B. T. N., Waldman, S., Stewart, E., Bays, D., Pappagianis, D. & Thompson, G. R., Dec 1 2018, In : Journal of Clinical Microbiology. 56, 12, e01318-18.

Research output: Contribution to journalArticle

Coccidioidomycosis
Lung
Meningitis
Confidence Intervals
Infection
3 Citations (Scopus)

Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome

Adhikari, A., Copping, N. A., Onaga, B., Pride, M. C., Coulson, R. L., Yang, M., Yasui, D. H., LaSalle, J. M. & Silverman, J. L., Jan 1 2018, (Accepted/In press) In : Neurobiology of Learning and Memory.

Research output: Contribution to journalArticle

Prader-Willi Syndrome
Aptitude
Phenotype
Small Nucleolar RNA
Learning
17 Citations (Scopus)

Colonocyte metabolism shapes the gut microbiota

Litvak, Y., Byndloss, M. X. & Baumler, A. J., Nov 30 2018, In : Science. 362, 6418, eaat9076.

Research output: Contribution to journalArticle

Anaerobic Bacteria
Microbiota
Homeostasis
Dysbiosis
Oxidative Phosphorylation
4 Citations (Scopus)

Comparative genomics of downy mildews reveals potential adaptations to biotrophy

Fletcher, K., Klosterman, S. J., Derevnina, L., Martin, F., Bertier, L. D., Koike, S., Reyes-Chin-Wo, S., Mou, B. & Michelmore, R. W., Nov 29 2018, In : BMC Genomics. 19, 1, 5214.

Research output: Contribution to journalArticle

Peronospora
Phytophthora
Genomics
Spinacia oleracea
Genes
1 Citation (Scopus)

Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation

Dou, J., Schmidt, R. J., Benke, K. S., Newschaffer, C., Hertz-Picciotto, I., Croen, L. A., Iosif, A-M., LaSalle, J. M., Fallin, M. D. & Bakulski, K. M., Feb 1 2018, (Accepted/In press) In : Epigenetics. p. 1-9 9 p.

Research output: Contribution to journalArticle

Blood Buffy Coat
DNA Methylation
Fetal Blood
Methylation
Glycocalyx
3 Citations (Scopus)

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy

Traglia, M., Croen, L. A., Jones, K. L., Heuer, L. S., Yolken, R., Kharrazi, M., DeLorenze, G. N., Ashwood, P., Van de Water, J. A. & Weiss, L. A., Aug 22 2018, In : Genome Medicine. 10, 1, 67.

Research output: Contribution to journalArticle

Genetic Crosses
Mothers
Pregnancy
Immune System
Chemokines
1 Citation (Scopus)

Cryopreservation of human mucosal tissues

Hughes, S. M., Ferre, A. L., Yandura, S. E., Shetler, C., Baker, C. A. R., Calienes, F., Levy, C. N., Astronomo, R. D., Shu, Z., Lentz, G. M., Fialkow, M., Kirby, A. C., Juliana McElrath, M., Sinclair, E., Rohan, L. C., Anderson, P. L., Shacklett, B., Dezzutti, C. S., Gao, D. & Hladik, F., Jul 1 2018, In : PLoS One. 13, 7, e0200653.

Research output: Contribution to journalArticle

Cryopreservation
cryopreservation
Mucous Membrane
Tissue
Vitrification
2 Citations (Scopus)
Bipolar Disorder
Schizophrenia
Cytokines
Brain
Interferons
15 Citations (Scopus)

Detection of HIV-1-specific gastrointestinal tissue resident CD8 + T-cells in chronic infection

Kiniry, B. E., Li, S., Ganesh, A., Hunt, P. W., Somsouk, M., Skinner, P. J., Deeks, S. G. & Shacklett, B., May 1 2018, In : Mucosal Immunology. 11, 3, p. 909-920 12 p.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Infection
Phenotype
Mucous Membrane
8 Citations (Scopus)

Differential expression of CD8+ T cell cytotoxic effector molecules in blood and gastrointestinal mucosa in HIV-1 infection

Kiniry, B. E., Hunt, P. W., Hecht, F. M., Somsouk, M., Deeks, S. G. & Shacklett, B., Mar 1 2018, In : Journal of Immunology. 200, 5, p. 1876-1888 13 p.

Research output: Contribution to journalArticle

Perforin
HIV Infections
HIV-1
Mucous Membrane
T-Lymphocytes
23 Citations (Scopus)

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

Rose, D. R., Yang, H., Serena, G., Sturgeon, C., Ma, B., Careaga, M., Hughes, H. K., Angkustsiri, K., Rose, M., Hertz-Picciotto, I., Van de Water, J. A., Hansen, R. L., Ravel, J., Fasano, A. & Ashwood, P., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Microbiota
Cytokines
Permeability
Autism Spectrum Disorder
Metagenome
Open Access
Tumor Necrosis Factor Receptors
Autistic Disorder
T-Lymphocytes
Tumor Necrosis Factor-alpha
Autism Spectrum Disorder
5 Citations (Scopus)

Effects of preservation method on canine (Canis lupus familiaris) fecal microbiota

Horng, K. R., Ganz, H. H., Eisen, J. A. & Marks, S. L., Jan 1 2018, In : PeerJ. 2018, 5, e4827.

Research output: Contribution to journalArticle

Canis lupus
Microbiota
Canidae
Dogs
dogs