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2020

Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures through a PKC-Dependent Mechanism

Ly, C., Shimizu, A. J., Vargas, M. V., Duim, W. C., Wender, P. A. & Olson, D. E., Jan 1 2020, (Accepted/In press) In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium

Jan, H. M., Chen, Y. C., Yang, T. C., Ong, L. L., Chang, C. C., Muthusamy, S., Abera, A. B., Wu, M. S., Gervay-Hague, J., Mong, K. K. T. & Lin, C. H., Dec 1 2020, In : Communications Biology. 3, 1, 120.

Research output: Contribution to journalArticle

Open Access

Comprehensive structural glycomic characterization of the glycocalyxes of cells and tissues

Li, Q., Xie, Y., Wong, M., Barboza Gardner, M. & Lebrilla, C. B., 2020, (Accepted/In press) In : Nature Protocols.

Research output: Contribution to journalArticle

Glycomic analysis of antibody indicates distinctive glycosylation profile in patients with autoimmune cholangitis

Zhou, X., Kailemia, M. J., Sun, Y., Shuai, Z., Yang, G. X., Dhaliwal, S., Cristoferi, L., Leung, P. S. C., Invernizzi, P., Bowlus, C., Lebrilla, C. B., Ansari, A. A., Ridgway, W. M., Zhang, W. & Gershwin, M. E., Jan 1 2020, (Accepted/In press) In : Journal of autoimmunity. 102503.

Research output: Contribution to journalArticle

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies

Dunlap, L. E., Azinfar, A., Ly, C., Cameron, L. P., Viswanathan, J., Tombari, R. J., Myers-Turnbull, D., Taylor, J. C., Grodzki, A. C., Lein, P. J., Kokel, D. & Olson, D. E., Feb 13 2020, In : Journal of medicinal chemistry. 63, 3, p. 1142-1155 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Influenza D virus diverges from its related influenza C virus in the recognition of 9-O-acetylated N-acetyl- or N-glycolyl-neuraminic acid-containing glycan receptors

Liu, R., Sreenivasan, C., Yu, H., Sheng, Z., Newkirk, S. J., An, W., Smith, D. F., Chen, X., Wang, D. & Li, F., Jun 2020, In : Virology. 545, p. 16-23 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

L. pneumophila CMP-5,7-di- N -acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues

McArthur, J. B., Santra, A., Li, W., Kooner, A. S., Liu, Z., Yu, H. & Chen, X., Jan 1 2020, In : Organic and Biomolecular Chemistry. 18, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans

Park, D. D., Phoomak, C., Xu, G., Olney, L. P., Tran, K. A., Park, S. S., Haigh, N. E., Luxardi, G., Lert-Itthiporn, W., Shimoda, M., Li, Q., Matoba, N., Fierro, F., Wongkham, S., Maverakis, E. & Lebrilla, C. B., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 7633-7644 12 p.

Research output: Contribution to journalArticle

Microarray analyses of closely related glycoforms reveal different accessibilities of glycan determinants on N-glycan branches

Li, L., Guan, W., Zhang, G., Wu, Z., Yu, H., Chen, X. & Wang, P. G., Apr 20 2020, In : Glycobiology. 30, 5, p. 334-345 12 p.

Research output: Contribution to journalArticle

Modified sialic acids on mucus and erythrocytes inhibit influenza a virus hemagglutinin and neuraminidase functions

Barnard, K. N., Alford-Lawrence, B. K., Buchholz, D. W., Wasik, B. R., LaClair, J. R., Yu, H., Honce, R., Ruhl, S., Pajic, P., Daugherity, E. K., Chen, X., Schultz-Cherry, S. L., Aguilar, H. C., Varki, A. & Parrish, C. R., Apr 1 2020, In : Journal of virology. 94, 9, e01567-19.

Research output: Contribution to journalArticle

1 Scopus citations

NIST interlaboratory study on glycosylation analysis of monoclonal antibodies: Comparison of results from diverse analytical methods

De Leoz, M. L. A., Duewer, D. L., Fung, A., Liu, L., Yau, H. K., Potter, O., Staples, G. O., Furuki, K., Frenkel, R., Hu, Y., Sosic, Z., Zhang, P., Altmann, F., Grunwald-Grube, C., Shao, C., Zaia, J., Evers, W., Pengelley, S., Suckau, D., Wiechmann, A. & 142 others, Resemann, A., Jabs, W., Beck, A., Froehlich, J. W., Huang, C., Li, Y., Liu, Y., Sun, S., Wang, Y., Seo, Y., An, H. J., Reichardt, N. C., Ruiz, J. E., Archer-Hartmann, S., Azadi, P., Bell, L., Lakos, Z., An, Y., Cipollo, J. F., Pucic-Bakovic, M., Štambuk, J., Lauc, G., Li, X., Wang, P. G., Bock, A., Hennig, R., Rapp, E., Creskey, M., Cyr, T. D., Nakano, M., Sugiyama, T., Leung, P. K. A., Link-Lenczowski, P., Jaworek, J., Yang, S., Zhang, H., Kelly, T., Klapoetke, S., Cao, R., Kim, J. Y., Lee, H. K., Lee, J. Y., Yoo, J. S., Kim, S. R., Suh, S. K., De Haan, N., Falck, D., Lageveen-Kammeijer, G. S. M., Wuhrer, M., Emery, R. J., Kozak, R. P., Liew, L. P., Royle, L., Urbanowicz, P. A., Packer, N. H., Song, X., Everest-Dass, A., Lattová, E., Cajic, S., Alagesan, K., Kolarich, D., Kasali, T., Lindo, V., Chen, Y., Goswami, K., Gau, B., Amunugama, R., Jones, R., Stroop, C. J. M., Kato, K., Yagi, H., Kondo, S., Yuen, C. T., Harazono, A., Shi, X., Magnelli, P. E., Kasper, B. T., Mahal, L., Harvey, D. J., O'Flaherty, R., Rudd, P. M., Saldova, R., Hecht, E. S., Muddiman, D. C., Kang, J., Bhoskar, P., Menard, D., Saati, A., Merle, C., Mast, S., Tep, S., Truong, J., Nishikaze, T., Sekiya, S., Shafer, A., Funaoka, S., Toyoda, M., De Vreugd, P., Caron, C., Pradhan, P., Tan, N. C., Mechref, Y., Patil, S., Rohrer, J. S., Chakrabarti, R., Dadke, D., Lahori, M., Zou, C., Cairo, C., Reiz, B., Whittal, R. M., Lebrilla, C. B., Wu, L., Guttman, A., Szigeti, M., Kremkow, B. G., Lee, K. H., Sihlbom, C., Adamczyk, B., Jin, C., Karlsson, N. G., Örnros, J., Larson, G., Nilsson, J., Meyer, B., Wiegandt, A., Komatsu, E., Perreault, H., Bodnar, E. D., Said, N., Francois, Y. N., Leize-Wagner, E., Maier, S., Zeck, A., Heck, A. J. R., Yang, Y., Haselberg, R., Yu, Y. Q., Alley, W., Leone, J. W., Yuan, H. & Stein, S. E., Jan 1 2020, In : Molecular and Cellular Proteomics. 19, 1, p. 11-30 20 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Production of functional mimics of human milk oligosaccharides by enzymatic glycosylation of bovine milk oligosaccharides

Weinborn, V., Li, Y., Shah, I. M., Yu, H., Dallas, D. C., German, J. B., Mills, D. A., Chen, X. & Barile, D., Mar 2020, In : International Dairy Journal. 102, 104583.

Research output: Contribution to journalArticle

Psychedelic Microdosing: Prevalence and Subjective Effects

Cameron, L. P., Nazarian, A. & Olson, D. E., Jan 1 2020, (Accepted/In press) In : Journal of Psychoactive Drugs.

Research output: Contribution to journalArticle

2 Scopus citations

Sensory and monosaccharide analysis of drip brew coffee fractions versus brewing time

Batali, M. E., Frost, S. C., Lebrilla, C. B., Ristenpart, W. D. & Guinard, J. X., Jan 1 2020, (Accepted/In press) In : Journal of the Science of Food and Agriculture.

Research output: Contribution to journalArticle

1 Scopus citations

Size-Controlled Chemoenzymatic Synthesis of Homogeneous Oligosaccharides of Neisseria meningitidis W Capsular Polysaccharide

Li, R., Yu, H., Muthana, S. M., Freedberg, D. I. & Chen, X., Feb 21 2020, In : ACS Catalysis. 10, 4, p. 2791-2798 8 p.

Research output: Contribution to journalArticle

The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites

Raetz, A. G., Banda, D. M., Ma, X., Xu, G., Rajavel, A. N., McKibbin, P. L., Lebrilla, C. B. & David, X. S. S., Mar 13 2020, In : Journal of Biological Chemistry. 295, 11, p. 3692-3707 16 p.

Research output: Contribution to journalArticle

Open Access

The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication

Nguyen, T., Lee, S., Yang, Y. A., Ahn, C., Sim, J. H., Kei, T. G., Barnard, K. N., Yu, H., Millano, S. K., Chen, X., Parrish, C. R. & Song, J., Jan 1 2020, In : PLoS pathogens. 16, 2, e1008336.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Three-Dimensional Printing of a Model Atomic Force Microscope to Measure Force-Distance Profiles

Gruber, D. M., Perez, T., Layug, B. Q., Ohama, M., Tran, L., Rojas, L. A. F., Garcia, A. X., Liu, G. Y. & Miller, W. J. W., Jan 1 2020, (Accepted/In press) In : Journal of Chemical Education.

Research output: Contribution to journalArticle

Open Access

Tunneling nanotubes mediate the expression of senescence markers in mesenchymal stem/stromal cell spheroids

Whitehead, J., Zhang, J., Harvestine, J. N., Kothambawala, A., Liu, G. Y. & Leach, J. K., Jan 1 2020, In : Stem Cells. 38, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

9-Azido-9-deoxy-2,3-difluorosialic Acid as a Subnanomolar Inhibitor against Bacterial Sialidases

Li, W., Santra, A., Yu, H., Slack, T. J., Muthana, M. M., Shi, D., Liu, Y. & Chen, X., Jun 7 2019, In : Journal of Organic Chemistry. 84, 11, p. 6697-6708 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

A Bacterial β1-3-Galactosyltransferase Enables Multigram-Scale Synthesis of Human Milk Lacto- N-tetraose (LNT) and Its Fucosides

McArthur, J. B., Yu, H. & Chen, X., Jan 1 2019, In : ACS Catalysis. p. 10721-10726 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

A Bump-Hole Approach for Directed RNA Editing

Monteleone, L. R., Matthews, M. M., Palumbo, C. M., Thomas, J. M., Zheng, Y., Chiang, Y., Fisher, A. J. & Beal, P. A., Feb 21 2019, In : Cell Chemical Biology. 26, 2, p. 269-277.e5

Research output: Contribution to journalArticle

6 Scopus citations

Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide

Juttukonda, L. J., Green, E. R., Lonergan, Z. R., Heffern, M., Chang, C. J. & Skaar, E. P., Jan 1 2019, In : Infection and Immunity. 87, 1

Research output: Contribution to journalArticle

13 Scopus citations

Analysis of Metal Effects on C-Peptide Structure and Internalization

Stevenson, M. J., Farran, I. C., Uyeda, K. S., San Juan, J. A. & Heffern, M., Jan 1 2019, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

1 Scopus citations

A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with near Quantitative Bidirectional Photoconversion

Zhu, J. S., Larach, J. M., Tombari, R. J., Gingrich, P. W., Bode, S. R., Tuck, J. R., Warren, H. T., Son, J. H., Duim, W. C., Fettinger, J. C., Haddadin, M. J., Tantillo, D. J., Kurth, M. J. & Olson, D. E., Nov 1 2019, In : Organic Letters. 21, 21, p. 8765-8770 6 p.

Research output: Contribution to journalArticle

A substrate tagging and two-step enzymatic reaction strategy for large-scale synthesis of 2,7-anhydro-sialic acid

Li, W., Ghosh, T., Bai, Y., Santra, A., Xiao, A. & Chen, X., Jun 1 2019, In : Carbohydrate Research. 479, p. 41-47 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Biochemical characterization of Helicobacter pylori α1–3-fucosyltransferase and its application in the synthesis of fucosylated human milk oligosaccharides

Bai, J., Wu, Z., Sugiarto, G., Gadi, M. R., Yu, H., Li, Y., Xiao, C., Ngo, A., Zhao, B., Chen, X. & Guan, W., Jul 1 2019, In : Carbohydrate Research. 480, p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy

Reuven, E. M., Leviatan Ben-Arye, S., Yu, H., Duchi, R., Perota, A., Conchon, S., Bachar Abramovitch, S., Soulillou, J. P., Galli, C., Chen, X. & Padler-Karavani, V., Mar 26 2019, In : ACS Nano. 13, 3, p. 2936-2947 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography

Matthews, M. M., McArthur, J. B., Li, Y., Yu, H., Chen, X. & Fisher, A. J., Jan 1 2019, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

1 Scopus citations

Chemoenzymatic Synthesis of O-Mannose Glycans Containing Sulfated or Nonsulfated HNK-1 Epitope

Gao, T., Yan, J., Liu, C. C., Palma, A. S., Guo, Z., Xiao, M., Chen, X., Liang, X., Chai, W. & Cao, H., Dec 11 2019, In : Journal of the American Chemical Society. 141, 49, p. 19351-19359 9 p.

Research output: Contribution to journalArticle

Development of an extensive linkage library for characterization of carbohydrates

Galermo, A. G., Nandita, E., Castillo, J. J., Amicucci, M. J. & Lebrilla, C. B., Jan 1 2019, (Accepted/In press) In : Analytical chemistry.

Research output: Contribution to journalArticle

2 Scopus citations

Differential recognition of diet-derived Neu5Gc-Neoantigens on glycan microarrays by carbohydrate-specific pooled human IgG and IgA antibodies

Leviatan Ben-Arye, S., Schneider, C., Yu, H., Bashir, S., Chen, X., Von Gunten, S. & Padler-Karavani, V., May 15 2019, In : Bioconjugate Chemistry. 30, 5, p. 1565-1574 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of serotransferrin glycoforms: Novel markers for diagnosis of liver periductal fibrosis and prediction of cholangiocarcinoma

Jamnongkan, W., Lebrilla, C. B., Barboza, M., Techasen, A., Loilome, W., Sithithaworn, P., Khuntikeo, N., Pairojkul, C., Chamadol, N., Thanan, R. & Yongvanit, P., Oct 2019, In : Biomolecules. 9, 10, 538.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Dry Transfer of van der Waals Crystals to Noble Metal Surfaces to Enable Characterization of Buried Interfaces

Krayev, A., Bailey, C. S., Jo, K., Wang, S., Singh, A., Darlington, T., Liu, G. Y., Gradecak, S., Schuck, P. J., Pop, E. & Jariwala, D., Oct 16 2019, In : ACS Applied Materials and Interfaces. 11, 41, p. 38218-38225 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of copper chelation on BRAFv600e positive colon carcinoma cells

Baldari, S., Di Rocco, G., Heffern, M., Su, T. A., Chang, C. J. & Toietta, G., May 1 2019, In : Cancers. 11, 5, p. 1-17 17 p., 659.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Effects of N-glycosylation on the structure, function, and stability of a plant-made fc-fusion anthrax decoy protein

Xiong, Y., Karuppanan, K., Bernardi, A., Li, Q., Kommineni, V., Dandekar, A. M., Lebrilla, C. B., Faller, R., McDonald, K. A. & Nandi, S., May 31 2019, In : Frontiers in Plant Science. 10, 768.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome

Le Berre, L., Danger, R., Mai, H. L., Amon, R., Leviatan Ben-Arye, S., Bruneau, S., Senage, T., Perreault, H., Teraiya, M., Nguyen, T. V. H., Le Tourneau, T., Yu, H., Chen, X., Galli, C., Roussel, J. C., Manez, R., Costa, C., Brouard, S., Galinanes, M., Harris, K. M. & 5 others, Gitelman, S., Cozzi, E., Charreau, B., Padler-Karavani, V. & Soulillou, J. P., Jan 1 2019, In : Xenotransplantation. e12535.

Research output: Contribution to journalArticle

5 Scopus citations

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

Bell, A., Brunt, J., Crost, E., Vaux, L., Nepravishta, R., Owen, C. D., Latousakis, D., Xiao, A., Li, W., Chen, X., Walsh, M. A., Claesen, J., Angulo, J., Thomas, G. H. & Juge, N., Dec 1 2019, In : Nature Microbiology. 4, 12, p. 2393-2404 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Enterococcus faecalis α1–2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification

Li, Y., Li, R., Yu, H., Sheng, X., Wang, J., Fisher, A. J. & Chen, X., Jan 1 2019, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR

Tombari, R. J., Saunders, C. M., Wu, C. Y., Dunlap, L. E., Tantillo, D. J. & Olson, D., Jan 1 2019, (Accepted/In press) In : ACS Chemical Biology.

Research output: Contribution to journalArticle

1 Scopus citations

Facile chemoenzymatic synthesis of Lewis a (Lea) antigen in gram-scale and sialyl Lewis a (sLea) antigens containing diverse sialic acid forms

Tasnima, N., Yu, H., Yan, X., Li, W., Xiao, A. & Chen, X., Jan 15 2019, In : Carbohydrate Research. 472, p. 115-121 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Function without Structures: The Need for In-Depth Analysis of Dietary Carbohydrates

Amicucci, M. J., Nandita, E. & Lebrilla, C. B., Apr 24 2019, In : Journal of Agricultural and Food Chemistry. 67, 16, p. 4418-4424 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human Milk Proteins and Their Glycosylation Exhibit Quantitative Dynamic Variations during Lactation

Goonatilleke, E., Huang, J., Xu, G., Wu, L., Smilowitz, J. T., German, J. B. & Lebrilla, C. B., Aug 1 2019, In : The Journal of nutrition. 149, 8, p. 1317-1325 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Identification of potential sialic acid binding proteins on cell membranes by proximity chemical labeling

Li, Q., Xie, Y., Xu, G. & Lebrilla, C. B., Jan 1 2019, In : Chemical Science. 10, 24, p. 6199-6209 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Immunoglobulin A N-glycosylation Presents Important Body Fluid-specific Variations in Lactating Mothers

Goonatilleke, E., Smilowitz, J. T., Mariño, K. V., German, B. J., Lebrilla, C. B. & Barboza, M., Nov 1 2019, In : Molecular & cellular proteomics : MCP. 18, 11, p. 2165-2177 13 p.

Research output: Contribution to journalArticle

Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages

Sun, Y., Reid, B., Ferreira, F., Luxardi, G., Ma, L., Lokken, K. L., Zhu, K., Xu, G., Sun, Y., Ryzhuk, V., Guo, B. P., Lebrilla, C. B., Maverakis, E., Mogilner, A. & Zhao, M., Apr 1 2019, In : PLoS biology. 17, 4, p. e3000044

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Label-Free and Direct Visualization of Multivalent Binding of Bone Morphogenetic Protein-2 with Cartilage Oligomeric Matrix Protein

Tran, V., Karsai, A., Fong, M. C., Cai, W., Yik, J. H. N., Klineberg, E. O., Haudenschild, D. R. & Liu, G., Oct 1 2019, In : Journal of Physical Chemistry B. 123, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Nod-like receptors are critical for gut–brain axis signalling in mice

Pusceddu, M. M., Barboza, M., Keogh, C. E., Schneider, M., Stokes, P., Sladek, J. A., Kim, H. J. D., Torres-Fuentes, C., Goldfild, L. R., Gillis, S. E., Brust-Mascher, I., Rabasa, G., Wong, K. A., Lebrilla, C., Byndloss, M. X., Maisonneuve, C., Bäumler, A. J., Philpott, D. J., Ferrero, R. L., Barrett, K. E. & 2 others, Reardon, C. & Gareau, M. G., Dec 1 2019, In : Journal of Physiology. 597, 24, p. 5777-5797 21 p.

Research output: Contribution to journalArticle

5 Scopus citations

Omics Forecasting: Predictive Calculations Permit the Rapid Interpretation of High-Resolution Mass Spectral Data from Complex Mixtures

Cave, J. R., Parker, E., Lebrilla, C. & Waterhouse, A. L., Jan 1 2019, (Accepted/In press) In : Journal of Agricultural and Food Chemistry.

Research output: Contribution to journalArticle