Biochemistry and Molecular Medicine

Research Output

2020

A fixed-target platform for serial femtosecond crystallography in a hydrated environment

Shelby, M. L., Gilbile, D., Grant, T. D., Seuring, C., Segelke, B. W., He, W., Evans, A. C., Pakendorf, T., Fischer, P., Hunter, M. S., Batyuk, A., Barthelmess, M., Meents, A., Coleman, M. A., Kuhl, T. L. & Frank, M., Jan 1 2020, In : IUCrJ. 7, p. 30-41 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A large-scale comparative study of isoform expressions measured on four platforms

Zhang, W., Petegrosso, R., Chang, J. W., Sun, J., Yong, J., Chien, J. & Kuang, R., Mar 30 2020, In : BMC Genomics. 21, 1, 272.

Research output: Contribution to journalArticle

Open Access

A master regulator of cholesterol biosynthesis constitutes a therapeutic liability of triple negative breast cancer

Cai, D., Zhang, X. & Chen, H. W., Mar 3 2020, In : Molecular and Cellular Oncology. 7, 2, 1701362.

Research output: Contribution to journalArticle

1 Scopus citations

A mouse model and 19F NMR approach to investigate the effects of sialic acid supplementation on cognitive development

Chung, Y., Mohanakrishnan, R., Brossmer, R., Gong, Q., Lönnerdal, B. & Jue, T., Jan 1 2020, In : FEBS Letters. 594, 1, p. 135-143 9 p.

Research output: Contribution to journalArticle

A novel bioengineered miR-127 prodrug suppresses the growth and metastatic potential of triple-negative breast cancer cells

Umeh-Garcia, M., Simion, C., Ho, P. Y., Batra, N., Berg, A. L., Carraway, K. L., Yu, A. & Sweeney, C., Feb 1 2020, In : Cancer Research. 80, 3, p. 418-429 12 p.

Research output: Contribution to journalArticle

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene

Halmai, J. A. N. M., Deng, P., Gonzalez, C. E., Coggins, N. B., Cameron, D., Carter, J. L., Buchanan, F. K. B., Waldo, J. J., Lock, S. R., Anderson, J. D., O'Geen, H., Segal, D. J., Nolta, J. & Fink, K. D., Mar 18 2020, In : Nucleic acids research. 48, 5, p. 2372-2387 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Author Correction: Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells (Nature Communications, (2014), 5, 1, (4430), 10.1038/ncomms5430)

Chen, C., Jiang, P., Xue, H., Peterson, S. E., Tran, H. T., McCann, A. E., Parast, M. M., Li, S., Pleasure, D. E., Laurent, L. C., Loring, J. F., Liu, Y. & Deng, W., Dec 1 2020, In : Nature communications. 11, 1, 1070.

Research output: Contribution to journalComment/debate

Open Access

Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (Nature Neuroscience, (2020), 23, 1, (15-20), 10.1038/s41593-019-0556-3)

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalComment/debate

Open Access

Bioengineered miR-328-3p modulates GLUT1-mediated glucose uptake and metabolism to exert synergistic antiproliferative effects with chemotherapeutics

Yi, W., Tu, M. J., Liu, Z., Zhang, C., Batra, N., Yu, A. X. & Yu, A. M., Jan 2020, In : Acta Pharmaceutica Sinica B. 10, 1, p. 159-170 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence

Wang, Y., Yu, T., Zhou, Y., Wang, S., Zhou, X., Wang, L., Ou, T., Chen, Y., Zhou, Y., Zhang, H., Wang, Y., Fan, X., Chen, P., Gonzalez, F. J., Yu, A., Huang, P., Huang, M. & Bi, H., Apr 14 2020, In : Aging. 12, 8, p. 6733-6755 23 p.

Research output: Contribution to journalArticle

Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects

International 22q11.2 Brain and Behavior Consortium, Jan 2 2020, In : American Journal of Human Genetics. 106, 1, p. 26-40 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Developmental aspects of FXAND in a man with the FMR1 premutation

Santos, E., Emeka-Nwonovo, C., Wang, J. Y., Schneider, A., Tassone, F., Hagerman, P. & Hagerman, R., Feb 1 2020, In : Molecular Genetics and Genomic Medicine. 8, 2, e1050.

Research output: Contribution to journalArticle

Open Access

Development of potent inhibitors of the human microsomal epoxide hydrolase

Barnych, B., Singh, N., Negrel, S., Zhang, Y., Magis, D., Roux, C., Hua, X., Ding, Z., Morisseau, C., Tantillo, D. J., Siegel, J. B. & Hammock, B. D., May 1 2020, In : European Journal of Medicinal Chemistry. 193, 112206.

Research output: Contribution to journalArticle

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Oe, Y., Wang, X., Patriarchi, T., Konno, A., Ozawa, K., Yahagi, K., Hirai, H., Tian, L., McHugh, T. J. & Hirase, H., Dec 1 2020, In : Nature communications. 11, 1, 471.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature Neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Editorial: Precise Genome Editing Techniques and Applications

Xu, K., Segal, D. J. & Zhang, Z., Apr 21 2020, In : Frontiers in Genetics. 11, 412.

Research output: Contribution to journalEditorial

Open Access

Erratum: Loci associated with skin pigmentation identified in African populations (Science (2020)367: 6475 (eaba7178)Doi:10.1126/science.aan8433)

NISC Comparative Sequencing Program, Jan 17 2020, In : Science. 367, 6475

Research output: Contribution to journalComment/debate

Open Access

Evaluating Protein Engineering Thermostability Prediction Tools Using an Independently Generated Dataset

Huang, P., Chu, S. K. S., Frizzo, H. N., Connolly, M. P., Caster, R. W. & Siegel, J. B., Jan 1 2020, (Accepted/In press) In : ACS Omega.

Research output: Contribution to journalArticle

Open Access

Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging

Yuan, Y., Bo, R., Jing, D., Ma, Z., Wang, Z., Lin, T. Y., Dong, L., Xue, X. & Li, Y., Jan 1 2020, (Accepted/In press) In : Nano Research.

Research output: Contribution to journalArticle

Fine mapping of the MHC region identifies major independent variants associated with Han Chinese primary biliary cholangitis

Wang, C., Zheng, X., Tang, R., Han, C., Jiang, Y., Wu, J., Shao, Y., Gao, Y., Yu, J., Hu, Z., Zang, Z., Zhao, Y., Dai, N., Liu, L., Wu, X., Nie, J., Jiang, B., Lin, M., Li, L., Wei, Y. & 29 others, Li, Y., Gong, Y., Dai, Y., Wang, L., Ding, N., Xu, P., Chen, S., Jiang, P., Wang, L., Qiu, F., Wu, Q., Zhang, M., Jawed, R., Chen, R., Zhang, Y., Shi, X., Zhu, Z., Pei, H., Huang, L., Tian, Y., Zhang, K., Qiu, H., Zhao, W., Gershwin, M. E., Chen, W., Seldin, M. F., Liu, X., Ma, X. & Sun, L., Feb 2020, In : Journal of autoimmunity. 107, 102372.

Research output: Contribution to journalArticle

Open Access

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion

Dodge, A., Peters, M. M., Greene, H. E., Dietrick, C., Botelho, R., Chung, D., Willman, J., Nenninger, A. W., Ciarlone, S., Kamath, S. G., Houdek, P., Sumová, A., Anderson, A. E., Dindot, S. V., Berg, E. L., O'Geen, H., Segal, D. J., Silverman, J. L., Weeber, E. J. & Nash, K. R., Jan 1 2020, (Accepted/In press) In : Autism Research.

Research output: Contribution to journalArticle

Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

International 22q11.2DS Brain and Behavior Consortium, Jan 1 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

3 Scopus citations

Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria

Cheng, X. Y., Biswas, S., Li, J., Mao, C. J., Chechneva, O., Chen, J., Li, K., Li, J., Zhang, J. R., Liu, C. F. & Deng, W. B., Apr 24 2020, In : Translational Neurodegeneration. 9, 1, 13.

Research output: Contribution to journalArticle

Open Access

Identification of structural variation in chimpanzees using optical mapping and nanopore sequencing

Soto, D. C., Shew, C., Mastoras, M., Schmidt, J. M., Sahasrabudhe, R., Kaya, G., Andrés, A. M. & Dennis, M. Y., Mar 2020, In : Genes. 11, 3, 276.

Research output: Contribution to journalArticle

Open Access

Impaired skeletal muscle mitochondrial bioenergetics and physical performance in chronic kidney disease

Kestenbaum, B., Gamboa, J., Liu, S., Ali, A. S., Shankland, E., Jue, T., Giulivi, C., Smith, L. R., Himmelfarb, J., de Boer, I. H., Conley, K. & Roshanravan, B., Mar 12 2020, In : JCI Insight. 5, 5, e133289.

Research output: Contribution to journalArticle

Open Access

Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system

Lefevre, E. M., Pisansky, M. T., Toddes, C., Baruffaldi, F., Pravetoni, M., Tian, L., Kono, T. J. Y. & Rothwell, P. E., Jan 1 2020, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

1 Scopus citations

Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade

Liu, L., Xie, B., Fan, M., Candas-Green, D., Jiang, J. X., Wei, R., Wang, Y., Chen, H. W., Hu, Y. & Li, J. J., Jan 27 2020, In : Developmental Cell. 52, 2, p. 196-209.e9

Research output: Contribution to journalArticle

Open Access

Macromolecular modeling and design in Rosetta: recent methods and frameworks

Leman, J. K., Weitzner, B. D., Lewis, S. M., Adolf-Bryfogle, J., Alam, N., Alford, R. F., Aprahamian, M., Baker, D., Barlow, K. A., Barth, P., Basanta, B., Bender, B. J., Blacklock, K., Bonet, J., Boyken, S. E., Bradley, P., Bystroff, C., Conway, P., Cooper, S., Correia, B. E. & 88 others, Coventry, B., Das, R., De Jong, R. M., DiMaio, F., Dsilva, L., Dunbrack, R., Ford, A. S., Frenz, B., Fu, D. Y., Geniesse, C., Goldschmidt, L., Gowthaman, R., Gray, J. J., Gront, D., Guffy, S., Horowitz, S., Huang, P. S., Huber, T., Jacobs, T. M., Jeliazkov, J. R., Johnson, D. K., Kappel, K., Karanicolas, J., Khakzad, H., Khar, K. R., Khare, S. D., Khatib, F., Khramushin, A., King, I. C., Kleffner, R., Koepnick, B., Kortemme, T., Kuenze, G., Kuhlman, B., Kuroda, D., Labonte, J. W., Lai, J. K., Lapidoth, G., Leaver-Fay, A., Lindert, S., Linsky, T., London, N., Lubin, J. H., Lyskov, S., Maguire, J., Malmström, L., Marcos, E., Marcu, O., Marze, N. A., Meiler, J., Moretti, R., Mulligan, V. K., Nerli, S., Norn, C., Ó’Conchúir, S., Ollikainen, N., Ovchinnikov, S., Pacella, M. S., Pan, X., Park, H., Pavlovicz, R. E., Pethe, M., Pierce, B. G., Pilla, K. B., Raveh, B., Renfrew, P. D., Burman, S. S. R., Rubenstein, A., Sauer, M. F., Scheck, A., Schief, W., Schueler-Furman, O., Sedan, Y., Sevy, A. M., Sgourakis, N. G., Shi, L., Siegel, J. B., Silva, D. A., Smith, S., Song, Y., Stein, A., Szegedy, M., Teets, F. D., Thyme, S. B., Wang, R. Y. R., Watkins, A., Zimmerman, L. & Bonneau, R., Jan 1 2020, (Accepted/In press) In : Nature Methods.

Research output: Contribution to journalArticle

Meltos: Multi-sample tumor phylogeny reconstruction for structural variants

Ricketts, C., Seidman, D., Popic, V., Hormozdiari, F., Batzoglou, S. & Hajirasouliha, I., Feb 15 2020, In : Bioinformatics. 36, 4, p. 1082-1090 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular Biomarkers Predictive of Sertraline Treatment Response in Young Children With Autism Spectrum Disorder

Alolaby, R. R., Jiraanont, P., Durbin-Johnson, B., Jasoliya, M., Tang, H. T., Hagerman, R. & Tassone, F., Apr 15 2020, In : Frontiers in Genetics. 11, 308.

Research output: Contribution to journalArticle

Open Access

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs

Yang, C. P., Yang, W. S., Wong, Y. H., Wang, K. H., Teng, Y. C., Chang, M. H., Liao, K. H., Nian, F. S., Chao, C. C., Tsai, J. W., Hwang, W. L., Lin, M. W., Tzeng, T. Y., Wang, P. N., Campbell, M., Chen, L. K., Tsai, T. F., Chang, P. C. & Kung, H. J., Jan 1 2020, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Open Access

Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure

Zhou, C. J., Ji, Y., Reynolds, K., McMahon, M., Garland, M. A., Zhang, S., Sun, B., Gu, R., Islam, M., Liu, Y., Zhao, T., Hsu, G. & Iwasa, J., Jan 1 2020, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Novel approaches for efficient in vivo fermentation production of noncoding RNAs

Yu, A. M., Batra, N., Tu, M. J. & Sweeney, C., Mar 1 2020, In : Applied Microbiology and Biotechnology. 104, 5, p. 1927-1937 11 p.

Research output: Contribution to journalReview article

Novel POFUT1 mutation in patient with flexural and acral hyperpigmented reticulated macules presenting in adolescence

Kiuru, M., Terrell, J. R., Gorouhi, F. & McPherson, J. D., Apr 2020, In : JAAD Case Reports. 6, 4, p. 334-336 3 p.

Research output: Contribution to journalArticle

Open Access

Parkinsonism Versus Concomitant Parkinson's Disease in Fragile X–Associated Tremor/Ataxia Syndrome

Salcedo-Arellano, M. J., Wolf-Ochoa, M. W., Hong, T., Amina, S., Tassone, F., Lechpammer, M., Hagerman, R. & Martínez-Cerdeño, V., Jan 1 2020, (Accepted/In press) In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

Patient-Centered Team-Based Learning in Pre-Clinical Curriculum Supporting the Application of Knowledge to Real-World Clinical Experience

Anderson, H., Sweeney, C., Perry, R., Vaquero, J. & Ison, H., Jan 1 2020, (Accepted/In press) In : Medical Science Educator.

Research output: Contribution to journalArticle

Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

Seo, J. W., Ingham, E. S., Mahakian, L., Tumbale, S., Wu, B., Aghevlian, S., Shams, S., Baikoghli, M., Jain, P., Ding, X., Goeden, N., Dobreva, T., Flytzanis, N. C., Chavez, M., Singhal, K., Leib, R., James, M. L., Segal, D. J., Cheng, R. H., Silva, E. A. & 2 others, Gradinaru, V. & Ferrara, K. W., Dec 1 2020, In : Nature communications. 11, 1, 2102.

Research output: Contribution to journalArticle

Open Access

Psychiatric and Medical Profiles of Autistic Adults in the SPARK Cohort

The SPARK Consortium, Jan 1 2020, (Accepted/In press) In : Journal of Autism and Developmental Disorders.

Research output: Contribution to journalArticle

Rainbow Kaposi's Sarcoma-Associated Herpesvirus Revealed Heterogenic Replication with Dynamic Gene Expression

Nakajima, K. I., Guevara-Plunkett, S., Chuang, F., Wang, K. H., Lyu, Y., Kumar, A., Luxardi, G., Izumiya, C., Soulika, A., Campbell, M. & Izumiya, Y., Mar 31 2020, In : Journal of virology. 94, 8

Research output: Contribution to journalArticle

Open Access

Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells

Hao, D., Fan, Y., Xiao, W., Liu, R., Pivetti, C., Walimbe, T., Guo, F., Zhang, X., Farmer, D. L., Wang, F., Panitch, A., Lam, K. S. & Wang, A., Jan 1 2020, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Rapidly progressing neurocognitive disorder in a male with fxtas and alzheimer’s disease

Aydin, E. Y., Schneider, A., Protic, D., Wang, J. Y., Martínez-Cerdeño, V., Tassone, F., Tang, H. T., Perlman, S. & Hagerman, R. J., Jan 1 2020, In : Clinical Interventions in Aging. 15, p. 285-292 8 p.

Research output: Contribution to journalArticle

Open Access

RAS pathway influences the number of melanocytic nevi in cardiofaciocutaneous and Costello syndromes

Kiuru, M., Urban, J., Zhu, G., Rybak, I., Terrell, J. R., Qi, L., McPherson, J. D., Marghoob, A. A. & Rauen, K. A., Jan 1 2020, (Accepted/In press) In : Journal of the American Academy of Dermatology.

Research output: Contribution to journalArticle

Rotatable Aggregation-Induced-Emission/Aggregation-Caused-Quenching Ratio Strategy for Real-Time Tracking Nanoparticle Dynamics

Wu, H., Zhang, L., Yang, J., Bo, R., Du, H., Lin, K., Zhang, D., Ramachandran, M., Shen, Y., Xu, Y., Xue, X., Ma, Z., Lindstrom, A. R., Carney, R., Lin, T. Y. & Li, Y., Jan 1 2020, (Accepted/In press) In : Advanced Functional Materials. 1910348.

Research output: Contribution to journalArticle

S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis

Wang, Q., Zheng, J., Zou, J. X., Xu, J., Han, F., Xiang, S., Liu, P., Chen, H. W. & Wang, J., Feb 1 2020, In : Chemico-Biological Interactions. 317, 108965.

Research output: Contribution to journalArticle

Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors

Wu, H., Lu, H., Xiao, W., Yang, J., Du, H., Shen, Y., Qu, H., Jia, B., Manna, S. K., Ramachandran, M., Xue, X., Ma, Z., Xu, X., Wang, Z., He, Y., Lam, K. S., Zawadzki, R. J., Li, Y. & Lin, T. Y., Jan 1 2020, (Accepted/In press) In : Advanced Materials. 1903759.

Research output: Contribution to journalArticle

Short-term organoid culture for drug sensitivity testing of high-grade serous carcinoma

Chen, H., Gotimer, K., De Souza, C., Tepper, C. G., Karnezis, A. N., Leiserowitz, G. S., Chien, J. & Smith, L. H., Jan 1 2020, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Signaling in and out: Long-noncoding RNAs in tumor hypoxia

Kuo, T. C., Kung, H. J. & Shih, J. W., May 5 2020, In : Journal of Biomedical Science. 27, 1, 59.

Research output: Contribution to journalReview article

Open Access

Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo-Chemo Combination Therapy

Cong, Z., Zhang, L., Ma, S. Q., Lam, K. S., Yang, F. F. & Liao, Y. H., Feb 25 2020, In : ACS Nano. 14, 2, p. 1958-1970 13 p.

Research output: Contribution to journalArticle

Structure–activity relationship of RGD-containing cyclic octapeptide and αvβ3 integrin allows for rapid identification of a new peptide antagonist

Silva, A., Xiao, W., Wang, Y., Wang, W., Chang, H. W., Ames, J. B., Lam, K. S. & Zhang, Y., May 1 2020, In : International journal of molecular sciences. 21, 9, 3076.

Research output: Contribution to journalArticle

Open Access